2. Signaling Pathways
  3. Neuronal Signaling
  4. Monoamine Oxidase

Monoamine Oxidase

MAO

Monoamine Oxidase

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Monoamine oxidases (MAO) are a family of enzymes that catalyze the oxidation of monoamines. They are found bound to the outer membrane of mitochondria in most cell types in the body. They belong to the protein family of flavin-containing amine oxidoreductases. Monoamine oxidases catalyze the oxidative deamination of monoamines. Oxygen is used to remove an amine group from a molecule, resulting in the corresponding aldehyde and ammonia. Monoamine oxidases contain the covalently bound cofactor FAD and are, thus, classified as flavoproteins. Because of the vital role that MAOs play in the inactivation of neurotransmitters, MAO dysfunction is thought to be responsible for a number of psychiatric and neurological disorders. MAO-A inhibitors act as antidepressant and antianxiety agents, whereas MAO-B inhibitors are used alone or in combination to treat Alzheimer’sand Parkinson’s diseases.

Monoamine Oxidase Isoform Specific Products:

Monoamine Oxidase Isoform Comparison
Cat. No. Product Name Effect Purity Chemical Structure
  • HY-123665
    PSB-1410
    		Inhibitor 99.22%
    PSB-1410 is a selective and competitive monoamine oxidase B (MAO-B) inhibitor with IC50 for human MAO-B and rat MAO-B Values are 0.23 and 1.01 nM respectively.
    PSB-1410
  • HY-123556
    SZV-558
    		Inhibitor
    SZV-558 is a potent and selective MAO-B inhibitor with IC50 values of 50 and 60 nM for rats and humans, respectively. SZV-558 can be used in studies of Parkinson's disease (PD) models.
    SZV-558
  • HY-W415287
    DL-Thyroxine
    		Inhibitor
    DL-Thyroxine, a thyroid hormone, is a monoamine oxidase inhibitor.
    DL-Thyroxine
  • HY-B1111R
    Amitraz (Standard)
    		Inhibitor
    Amitraz (Standard) is the analytical standard of Amitraz. This product is intended for research and analytical applications. Amitraz is a non-systemic acaricide and insecticide with alpha-adrenergic agonist activity that interacts with octopamine receptors in the central nervous system and inhibits monoamine oxidase and prostaglandin synthesis.
    Amitraz (Standard)
  • HY-14205
    NW-1772
    		Inhibitor
    NW-1772 (methanesulfonate) (compound 22b) is a potent and selective monoamine oxidase (MAO) B inhibitor. NW-1772 has some advantages, such as rapid blood-brain barrier penetration, short-acting and reversible inhibitory activity, slight inhibition of selected cytochrome P450s, and low in vitro toxicity. NW-1772 can be used for the research of neurodegenerative diseases.
    NW-1772
  • HY-122128
    Lilly 51641
    		Inhibitor
    Lilly 51641 (LY-51641) is a selective and orally active Type A monoamine oxidase inhibitor. Lilly 51641 has the potential for the research of depressed and schizophrenic.
    Lilly 51641
  • HY-157392
    hMAO-A-IN-1
    		Inhibitor
    hMAO-A-IN-1 (compound 8) is a potent hMAO-A inhibitor, with an IC50 of 90 nM. hMAO-A-IN-1 can be used for the research of anxiety and depression.
    hMAO-A-IN-1
  • HY-59059
    5-(2-Aminopropyl)indole
    		Inhibitor
    5-(2-Aminopropyl)indole is an orally active psychoactive substance, that shows inhibitory activity against monoamine oxidase (MAO) and long-lasting stimulatory properties.
    5-(2-Aminopropyl)indole
  • HY-70057R
    Safinamide (Standard)
    		Inhibitor
    Safinamide (Standard) is the analytical standard of Safinamide. This product is intended for research and analytical applications. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 µM) over MAO-A (IC50=580 µM). Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8 µM) than at resting (IC50=262 µM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al.
    Safinamide (Standard)
  • HY-105127
    Brofaromine hydrochloride
    		Inhibitor
    Brofaromine (hydrochloride) is a monoamine oxidase A (MAO-A) inhibitor and a 5-HT uptake inhibitor. Brofaromine (hydrochloride) shows antidepressant-like activity in the social conflict test in rats.
    Brofaromine hydrochloride
  • HY-164649
    Atibeprone
    		Inhibitor
    Atibeprone (Lu 53439) is a selective MAO-B inhibitor. Atibeprone has antidepressant activity.
    Atibeprone
  • HY-W721302
    2-APB hydrochloride
    		Inhibitor
    2-APB is an analog of 6-APB, a benzofuran derivative and a psychoactive substance. Certain benzofuran derivatives have monoamine oxidase-A inhibitory activity .
    2-APB hydrochloride
  • HY-W700241
    Norharman-d7
    		Inhibitor
    Norharman-d7 is deuterium labeled Norharmane. Norharmane (Norharman), a β-carboline alkaloid, is a potent and reversible monoamine oxidase inhibitor, with IC50 values of 6.5 and 4.7 μM for MAO-A and MAO-B, respectively. Norharmane causes antidepressant responses. Norharmane is also a prospective anti-cancer photosensitizer. Norharmane alters polar auxin transport (PAT) by inhibiting PIN2, PIN3 and PIN7 transport proteins, thus causing a significant inhibitory effect on the growth of Arabidopsis thaliana seedlings.
    Norharman-d<sub>7</sub>
  • HY-A0091AR
    Pargyline (Standard)
    		Inhibitor
    Pargyline (Standard) is the analytical standard of Pargyline. This product is intended for research and analytical applications. Pargyline is an irreversible monoamine oxidase (MAO) inhibitor with Kis of 13 μM and 0.5 μM for MAO-A and MAO-B, respectively. Pargyline has antihypertensive and anticancer activities. Pargyline is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
    Pargyline (Standard)
  • HY-19333A
    OG-L002 hydrochloride
    		Inhibitor
    OG-L002 hydrochloride is a potent and highly selective LSD1 inhibitor with an IC50 of 0.02 μM. OG-L002 hydrochloride is a potent monoamine oxidases (MAO) inhibitor with IC50s of 1.38 μM and 0.72 μM for MAO-A and MAO-B, respectively. OG-L002 hydrochloride potently inhibits the expression of HSV IE genes.
    OG-L002 hydrochloride
  • HY-129444
    MD 780236 free base
    		Inhibitor
    MD 780236 free base is a substrate and selective inhibitor of monoamine oxidase B (MAO-B), competitive with phenylethylamine and 5-hydroxytryptamine (5-HT).
    MD 780236 free base
  • HY-70057S4
    Safinamide-d5
    		Inhibitor
    Safinamide-d5 (FCE 26743-d5) is deuterium labeled Safinamide. Safinamide is a potent, selective, and reversible monoamine oxidase B (MAO-B) inhibitor (IC50=0.098 μM) over MAO-A (IC50=580 μM). Safinamide also blocks sodium channels and modulates glutamate (Glu) release, showing a greater affinity at depolarized (IC50=8?μM) than at resting (IC50=262?μM) potentials. Safinamide has neuroprotective and neurorescuing effects and can be used for the study of parkinson disease, ischemia stroke etc.al.
    Safinamide-d<sub>5</sub>
  • HY-119774
    Caroxazone
    		Inhibitor
    Caroxazone is a reversible inhibitor for monoamine oxidase (MAO). Caroxazone exhibits activity as an antidepressant agent.
    Caroxazone
  • HY-N13041
    Acacetin 7-O-(6-O-malonylglucoside)
    		Inhibitor
    Acacetin 7-O-(6-O-malonylglucoside) is a monoamine oxidase inhibitor with strong inhibitory effects on monoamine oxidase A (MAO-A) and monoamine oxidase B (MAO-B) with IC50 values ​​of 2.34 and 1.87 μM, respectively. Acacetin 7-O-(6-O-malonylglucoside) is a reversible MAO inhibitor that can be used in the research of neurodegenerative diseases and affective disorders.
    Acacetin 7-O-(6-O-malonylglucoside)
  • HY-W017118A
    2,6-Dimethoxybenzylamine hydrochloride
    		Inhibitor
    2,6-Dimethoxybenzylamine hydrochloride (Compound 5) exhibits reversible inhibitory activity against copper amine oxidase (CAO), that inhibits benzylamine oxidase (BAO) and monoamine oxidase B (MAO B) with IC50 of 120 μM and 190 μM.
    2,6-Dimethoxybenzylamine hydrochloride
Cat. No. Product Name / Synonyms Application Reactivity
Monoamine Oxidase Isoform Comparison

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